This article introduces cued and contextual fear conditioning as methods for studying learning and memory in rodents. It explains how researchers pair sounds or environments with mild shocks to observe fear responses, helping to reveal how the brain processes and stores fear-related memories. The piece is especially useful for understanding behavioral research in genetically modified or motor-impaired animals.

This study investigates a therapeutic antibody targeting TREM2, a receptor expressed in microglia, the brain’s resident immune cells. The antibody stimulates microglial proliferation and survival, offering a potential strategy for modulating immune responses in neurodegenerative diseases like Alzheimer’s.